Molecular Glues Market Size, Share & Trend Analysis, By Type, By Function, Regional Outlook, Competitive Tactics, and Segment Forecast to 2030

Molecular Glues Market Size, Share & Trend Analysis, By Type, By Function, Regional Outlook, Competitive Tactics, and Segment Forecast to 2030

Category : Chemical & Industrial Material Reports | Delivery Format : PDF,PPT | Publisher: Reports & Insights | Pages : 250+ | Published on : January 2023

Molecular Glues Market Introduction:

It wasn't until the beginning of the 1990s that the term "molecular glue" became popular. The initial examples of molecular glues were the immunosuppressants cyclosporine A (CsA) and FK506. The expression "molecular glue (MG)" has been used to refer to scaffolding and anchoring proteins that are used to spatiotemporally limit and organize different types of kinase and/or phosphatase signaling cascades in cells. Molecular glues are significantly smaller, have excellent therapeutic qualities, and have high atomic availability.

Molecular glues are monovalent tiny compounds that facilitate protein-protein interactions by utilizing the secondary structural features of the target protein. The target protein can establish a binding area with some of the residues of the molecular glue when it attaches to the target protein, mediating the interaction between the target protein and the "recruited protein(s)". Such polynary complexes subsequently have several biological processes, including transporter inhibition, complex stabilization, interactome regulation, and protein degradation.

This market study on the global molecular glues market aims to cover market dynamics such as market drivers, challenges/restraints, and opportunities for the market players. It will also cover market segmentation outlook, molecular glues market trend, regional outlook, molecular glues market size, and market share, as well as industry and product insights, SWOT analysis, Porter's five force analysis, PESTEL analysis, heat map analysis, market forecast, and the major players operating in the molecular glues market.

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Scope of the Report:

Report Metric

Report Details

Market size available for the years


Base year


Forecast Period


Segments Covered

By Type, By Function, and By Region

Regions Covered

North America, Latin America, Asia Pacific, Europe, Middle East, and Africa

Key Players

Bristol Myers Squibb, Degron Therapeutics, Novartis, Seed Therapeutics, TRIANA Biomedicines, XlynX Materials, Proxygen, Pfizer, Almirall, IRB Barcelona, and among others.


Molecular Glues Market Drivers: Technological Advancement

The market for molecular glue is anticipated to grow soon due to the rise in the need for adhesives. Additionally, research on molecular glue's medicinal properties is being done, which will increase its use even more. With their ability to couple proteins, molecular glues offer an alternative by bringing proteins together and creating new protein-protein interactions that disrupt disease biology.

The market for molecular glue is experiencing technological breakthroughs. Businesses are working to create new and improved processes for making these molecular glues. During the projected period, the molecular glue market is anticipated to grow due to the development of new manufacturing processes and an increase in its usage. For instance, a Danish research team has created a new nanotechnology that enhances the molecular bonding between plastic and metal during the past years.


Molecular Glues Market Restraints: Existence of Alternative glues

The main obstacle will be finding the proper "glue" to support the protein degradation. The discovery of new alternative glues and the high cost associated with the manufacturing of molecular glues may limit the escalation of the molecular glues market.


Molecular Glues Market Opportunities: Demand in various End-Use Sectors

The advancement in new cutting-edge technologies, elevated demand for molecular glues in various sectors such as healthcare, and the chemical sector, and user-friendly properties of the molecular glues will provide giant opportunities for the global molecular glues market players. Potential biological pathways and new therapies are revealed by the development of proximity-induced protein breakdown technology using molecular glue. Drug development based on molecular glue is still in its early stages at the moment. The creation of practical structure-based molecular glue drug discovery tools is thus urgently required. 


Molecular Glues Market Trends:

The term "molecular glue" was invented by Stuart Schreiber about immunophilins in 1992. To modify biological processes, molecular glues can precisely promote protein aggregation between two or more proteins. The usage of molecular glues as protein degraders has grown significantly in recent years. However, molecular glues also perform several crucial roles, including complex stabilization, interactome regulation, and transporter inhibition, making it possible to drug difficult therapeutic targets and providing an intriguing new method for drug discovery. Since the majority of molecular glues are discovered by accident, it is crucial to investigate their systematic discovery and logical design. According to their aggregation modalities, examples of molecular glues are mediating homo-dimerization, homo-polymerization, and hetero-dimerization.

The "molecular glue" has two possible uses: it can bind to either the target protein or the enzyme known as an E3 ligase. The protein binding sites are somewhat altered in both cases, making them better suited to lining up and initiating the ubiquitination process.


Molecular Glues Market, by Type:

Based on the Type, the global molecular glues market is segmented into; Lenalidomide, Pomalidomide, Thalidomide, and its analogs.


Molecular Glues Market, by Function:

Based on the Function, the global molecular glues market is segmented into; Binding to the E3 ligase, Binding to the target protein.


Molecular Glues Market, by Region:

During the forecast period, Europe and North America are predicted to account for a significant portion of the worldwide molecular glue market. The molecular glue market in North America is anticipated to grow significantly between 2022 and 2030 as a result of an increase in demand from the skin care industries. Due to a rise in demand for this molecular glue in the European region's healthcare industry, Europe is predicted to be a lucrative molecular glue market between 2022 and 2030.

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Frequently Asked Questions

The global molecular glues market in 2022 is estimated for more than US$ *** Mn and expected to reach a value of US$ *** Mn by 2030 with a significant CAGR of ***%.

The base year for the report is 2021 in molecular glues market.

Molecular glues market is segmented on the basis of technology, type, application, and region

Bristol Myers Squibb, Degron Therapeutics, Novartis, Seed Therapeutics, TRIANA Biomedicines, XlynX Materials, Proxygen, Pfizer, Almirall, IRB Barcelona, and among others.

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